Transforming medical devices for improved patient outcomes

Publications

Evaluation of the MiStent sustained sirolimus eluting biodegradable polymer coated stent for the treatment of coronary artery disease: does uniform sustained abluminal drug release result in earlier strut coverage and better safety profile?

Ruben Y.G. Tijssen, Robin P. Kraak, Huangling Lu, Jeffrey G. Mifek, Wenda C. Carlyle, Dennis J. Donohoe, Robbert J. De Winter, Karel T. Koch and Joanna J. Wykrzykowska Taylor & Francis Group, Expert Review of Medical Devices 2017; Published online 24 April 2017; 1-10

Evolution of Drug-Eluting Stent Drug Elution Profile: Is A Crystalline Drug Form the Ideal Solution?

Giuseppe Sangiorgi, MD; Riccardo Colantonio, MD, PhD; Fabio De Luca, MD European Medical Journal Interventional Cardiology. June 2016; 4(1):55-67

Technical Overview On the MiStent Coronary Stent

James B. McClain, PhD; Wenda C. Carlyle, PhD; Dennis J. Donohoe, MD; John A. Ormiston, MB, ChB Minerva Cardioangiologica. in press. Epub ahead of print May 2016

Comparison of the Absorbable Polymer Sirolimus-Eluting Stent (MiStent) to the Durable Polymer Everolimus-Eluting Stent (Xience) (from the DESSOLVE I/II and ISAR-TEST-4 Studies)

Alexandra J. Lansky, M.D.; Adnan Kastrati, M.D.; Elazer R. Edelman, M.D., Ph.D.; Helen Parise, Sc.D.; Vivian G. Ng, M.D.; John Ormiston, M.D.; William Wijns, M.D.; and Robert A. Byrne, M.B., B.Ch., Ph.D. American Journal of Cardiology, February 15, 2016, Volume 117, Issue 4, pp 532-538.

Evaluation of a crystalline sirolimus-eluting coronary stent with a bioabsorbable polymer designed for rapid dissolution: two-year outcomes from the DESSOLVE I and II trials

William Wijns, M.D., Ph.D.; Maarten Jan Suttorp, M.D., Ph.D.; Leszek Zagozdzon, M.D.; Marie-Claude Morice, M.D.; Dougal McClean, M.D.; Pieter Stella, M.D.; Dennis Donohoe, M.D.; Charlene Knape, M.T.; John Ormiston, M.B.Ch.B. for the DESSOLVE I and DESSOLVE II Investigators EuroIntervention 2015 11-online publish-ahead-of-print September 2015

Bioabsorbable Polymer-Coated Sirolimus-Eluting Stent Implantation Preserves Coronary Vasomotion: A DESSOLVE II Trial Sub-study

Dan Rusinaru, M.D., Ph.D.; Mathias Vrolix, M.D.; Stefan Verheye, M.D.; Saqib Chowdhary, M.D., Ph.D.; Danny Schoors, M.D.; Carlo Di Mario, M.D., Ph.D.; Walter Desmet, M.D., Ph.D.; Dennis J. Donohoe, M.D.; John A. Ormiston, MB, ChB, Ph.D.; Charlene Knape, M.T.; Hiram Bezerra, M.D., Ph.D.; Alexandra Lansky, M.D.; and William Wijns, M.D., Ph.D. on behalf of the DESSOLVE II Investigators Catheterization and Cardiovascular Interventions 2015 86(7):1141-1150

Randomised Study of a Bioabsorbable Polymer-Coated Sirolimus-Eluting Stent: Results of the DESSOLVE II Trial

William Wijns, M.D., Ph.D.; Mathias Vrolix, M.D.; Stefan Verheye, M.D., Ph.D.; Danny Schoors, M.D., Ph.D.; Ton Slagboom, M.D.; Marcel Gosselink, M.D.; Edouard Benit, M.D.; Dennis Donohoe, M.D.; Charlene Knape, M.T.; Guilherme F. Attizzani, M.D.; Alexandra J. Lansky, M.D.; John Ormiston, M.D.; the DESSOLVE II Investigators EuroIntervention 2015 10(12):1383-1390

Serial Assessment by Optical Coherence Tomography of Early and Late Vascular Responses After Implantation of an Absorbable-Coating Sirolimus-Eluting Stent (from the First-in-Human DESSOLVE I Trial)

Guilherme F. Attizzani, M.D.; Hiram G. Bezerra, M.D., Ph.D.; John Ormiston, M.B.Ch.B.; Wei Wang, Ph.D.; Dennis Donohoe, M.D.; William Wijns, M.D., Ph.D.; Marco A. Costa, M.D., Ph.D.
The American Journal of Cardiology 2013 112(10):1557-1564

First-In-Human Evaluation of a Bioabsorbable Polymer-Coated Sirolimus-Eluting Stent Imaging and Clinical Results of the DESSOLVE I Trial 

John Ormiston, M.B.Ch.B.; Mark Webster, M.B.Ch.B.; James Stewart, M.B.Ch.B.; Mathias Vrolix, M.D.; Robert Whitbourn, M.B.B.S.; Dennis Donohoe, M.D.; Charlene Knape, M.T.; Alexandra Lansky, M.D.; Guilherme F. Attizzani, M.D.; Peter Fitzgerald, M.D., Ph.D.; David E. Kandzari, M.D.; William Wijns, M.D., Ph.D. Journal of American College of Cardiology: Cardiovascular Interventions 2013 6(10):1026-1034

Serial Evaluation of Vascular Response After Implantation of a New Sirolimus-Eluting Stent With Bioabsorbable Polymer (MISTENT®): An Optical Coherence Tomography and Histopathological Study

Guilherme F. Attizzani, M.D.; Hiram G. Bezerra, M.D., Ph.D.; Daniel Chamié, M.D.; Yusuke Fujino, M.D.; Anna-Maria Spognardi; James R.L. Stanley, M.S.D.V.M.; Hirosada Yamamoto, M.D., Emile Mehanna, M.D., Wei Wang, M.S.; Wenda C. Carlyle, Ph.D.; James B. McClain, Ph.D.; Marco A. Costa, M.D., Ph.D. Journal of Invasive Cardiology 2012; 24(11):560‐568

Enhanced Drug Delivery Capabilities from Stents Coated with Absorbable Polymer and Crystalline Drug

Wenda C. Carlyle, Ph.D.; James B. McClain, Ph.D.; Abraham R. Tzafriri, Ph.D.; Lynn Bailey; Brett G. Zani, Ph.D.; Peter M. Markham; James R.L. Stanley, M.S., D.V.M.; Elazer R. Edelman, M.D., Ph.D. Journal of Controlled Release 2012; 162(3):561-567